Exploration 3: Is developmental scaling used during somitogenesis by any ectotherm?
(under construction)
Background 8 introduced the prevalence of the Uniform Temperature Performance Curve (UTPC) equation in ectotherms, where the rate of many processes as a function of temperature can be expressed as a simple function of only 3 parameters; the temperature at the maximum rate, this maximum rate, and the (higher) temperature at which the rate goes to 0.
The idea of developmental scaling is that in ectotherms many higher level developmental processes might be coordinated by having their lower level processes all being adapted. to the same UTPC. Does this actually occur in any ectotherm, and what departures from this behavior have occurred during the evolution of endothermy and homeothermy.
Here I examine whether some processes in somitogenesis fit into the UTPC framework in species in which it has been most extensively studied, namely zebrafish (
1. Initiation of Hox gene expression
2. Migration through the primitive streak
3. Cell growth, division, and migration in the presomitic mesoderm
4. Clock and wavefront determination of somite size and position